Masanobu Iwanaga Miharu Eguchi Shinichi Enami Yasuko Osakada Hiroyuki Katsuki
Tetsuo Kishimoto Daisuke Kojima Akitoshi Koreeda Takuya Satoh Atsushi Syouji
Hiroki Takahashi Fumio Takahashi Hidehiko Nakagawa Biju V. Pillai  

* 5Years

Chemical donors for two-photon uncaging of gaseous cellular mediators to probe oxidative stress

Hidehiko Nakagawa

Nagoya City University, Graduate School of Pharmaceutical Sciences
Professor

URL : http://www.phar.nagoya-cu.ac.jp/hp/ykg/Yakka/index_english.html

Research Theme

Focusing on nitric oxide and related gaseous mediators, the project aims to realize ultrafine temporal and spatial control of these cellular mediators to elucidate biological significance of them. It is considered to be achieved in combination of novel two-photon-operating organelle-specific chemical donors of gaseous mediators with focused pulse laser technologies. The outcomes of this project are expected to deepen the understanding of biology of these mediators, and to be potentially applicable to therapeutic methods for the diseases involving the mediators.